Palermo, A.; Zaccaria, F.; Ninni, A.; Naciu, A. M.; Sciarretta, F.; Verteramo, L.; Gentile, C.; Barbetti, V. A.; Nevi, L.; Tabacco, G.; Conti, G.; Galli, F.; Menale, C.; Tuccinardi, D.; Longo, F.; Crucitti, P.; Taffon, C.; Crescenzi, A.; AQUILANO, K.; Carotti, S.; Sbardella, D.; Lettieri Barbato, D.

Preclinical models implicate the parathyroid hormone/parathyroid-hormone-related protein (PTH/PTHrP)-PTH1 receptor (PTH1R) axis in adipocyte lipolysis, adipose browning, and energy wasting. Whether this catabolic program is reproduced in vivo in humans remains unresolved. Primary hyperparathyroidism (PHPT), a condition of chronic endogenous PTH excess, provides a clinically relevant model to test the translational relevance of this pathway.