Shirzadian, M.; Gollob, E.; Reiter, C.; Rauter, U.; Paschinger, M.; Caballero, C.; Rinnerthaler, M.; Spiess, K.

What if language is not only a medium for human connection but a vibrational force that leaves structural traces in living cells? This study explores how audible sound, especially structured components of human speech, affects the cytoskeleton of Saccharomyces cerevisiae. Using a direct-contact acoustic system, we exposed yeast to distinct sound types: tonal vibrations, broadband noise, and consonant phonemes. Fluorescence microscopy revealed that tonal stimuli with coherent low-frequency patterns enhanced actin polymerization and shmoo formation, both markers of polarity and mating. In contrast, broadband noise disrupted actin integrity, while consonants produced no measurable effects. These results suggest that rhythmic continuity and spectral coherence, key features of speech, can modulate cytoskeletal organization in non-auditory cells. By reframing language as mechanical input rather than semantic content, this study bridges microbial cell biology with acoustic ecology and proposes a new lens for exploring how human soundscapes physically influence living systems.