Truong-Thien, P.; Nguyen Tuan, A.; Si, T. N.

Early diagnosis and treatment of Candida auris (C. auris) infections help improve mortality rates. At Cho Ray Hospital, we successfully isolated and identified C. auris in all clinical specimens using the Vitek 2 and Vitek MS systems. In Vietnam, there have been no prior reports on the antifungal susceptibility of C. auris. In this article, we present the first report on the antifungal susceptibility of C. auris in Vietnam (specifically at Cho Ray Hospital), using the broth microdilution method recommended by CLSI. We employed the Sensititre YeastOne - YO10 antifungal panel, and the susceptibility (S) rates of C. auris were 81.6% to caspofungin, 94.7% to fluconazole, and 71.1% to amphotericin B. The rate of resistance to all three antifungal drug classes (azoles, echinocandins, and polyenes) was 0%, while resistance to two antifungal drug classes accounted for 7.9% (3/38 isolates), and resistance to one of the three drug classes was observed in 36.8% of cases. Additionally, we assessed the relatedness of 38 C. auris isolates using two methods: broth microdilution combined with colorimetric analysis (Sensititre YeastOne - YO10) and gradient diffusion (Etest) according to US CDC standards. This allows laboratories to have multiple options for selecting methods that best suit their existing conditions.