Vinals, J.; Angheluta, L.; Alford, P. W.

Organogenesis involves large deformations and complex shape changes that require elaborate mechanical regulation. Models of tissue biomechanics have been introduced to account for the coupling between mechanical response and biochemical processes. Recent experimental evidence indicates that the mechanical response of epithelial tissue is strongly anisotropic, with the degree of anisotropy being correlated with the existence of long range orientational order of cytoskeletal organization across the tissue. A theoretical framework is introduced that captures the dynamic feedback between tissue elastic response and cy- toskeletal reorganization under stress. Within the linear regime for small and uniform applied strains, the shear modulus is effectively reduced by the nematic order in cytoskele- tal alignment induced by the applied strain. This prediction agrees with experimental observations of epithelial response in lithographically patterned micro tissues.