Kidder, B. L.

Modern biomedical imaging workflows generate large volumes of derived images and short videos that must be reviewed, compared, curated, and reused following primary acquisition and analysis. In practice, these assets are often dispersed across nested filesystem hierarchies on local drives, external media, or network storage, limiting efficient retrieval, deduplication, and figure assembly. We present PixelDeck, an open-source, local-first browser application for organizing and interactively browsing large biomedical image and video libraries on commodity workstations. PixelDeck integrates recursive folder import, SHA-256-based duplicate detection, metadata extraction, thumbnail and preview generation, full-text search, and asynchronous export within a responsive interface, supported by a modular ingestion pipeline, managed storage layer, and interactive browsing environment optimized for high-volume media collections. The system is implemented using a Next.js and React frontend, a SQLite metadata store accessed via Prisma, managed local media storage, and a background worker that executes import and export tasks asynchronously, enabling scalable processing on standard hardware. To evaluate performance, we conducted structured benchmark imports using public histopathology images curated from PanopTILs, SICAPv2, and PanNuke datasets, where dataset-specific import behavior, duplicate detection, and ingestion metrics were recorded as reproducible outputs. Embedding-based analysis further demonstrates dataset-level separation consistent with underlying image characteristics. These results show that PixelDeck provides an efficient, scalable local curation layer for heterogeneous biomedical imaging collections, enabling streamlined dataset exploration and preparation for downstream analysis.