Yong, S.; Hamidi, H.; Iacopino, D.; Beeby, S.

Flexible and textile-integrated electrochemical systems offer a convenient, user-friendly and noninvasive platform for continuous biochemical monitoring. In this study, a fully flexible and low-profile electrochemical system was developed by fabricating both the glucose biosensor and a compact potentiostat implemented on a polyimide (PI) filament circuit. The glucose biosensor was realized via direct laser writing (DLW), enabling precise electrode patterning and seamless integration with the potentiostat filament circuit. The integrated system exhibited a linear chronoamperometric response to glucose concentrations ranging from 0 to 0.25 mM in artificial sweat (AS). Further evaluation on cotton textiles soaked in AS and under mechanical bending confirmed stable performance, flexibility, and robustness. These findings highlight the potential of the PI-based potentiostat-sensor system for wearable, textile-integrated glucose monitoring and broader healthcare applications.