Pharmacology and Toxicology

Acute Exposure to Perfluorooctanoic Acid (PFOA) During Cardiomyogenesis disrupts Transcriptional and Electrophysiological Profiles in Differentiated Myocytes

Acute Exposure to Perfluorooctanoic Acid (PFOA...

Pharmacology and Toxicology
Avatar
librarian
4 views
Model-supported patient stratification using multi-objective synergy optimization in combination therapy

Model-supported patient stratification using m...

Pharmacology and Toxicology
Avatar
librarian
4 views
Development of approaches to overcome the drop in hematocrit when implementing mononuclear phagocyte system cytoblockade in vivo used to prolong the circulation of nanoparticles in the blood

Development of approaches to overcome the drop...

Pharmacology and Toxicology
Avatar
Elizaveta Mochalova
6 views
Tocilizumab induces significant changes in longitudinal proteomes of blood serum from patients with severe COVID-19 pneumonia

Tocilizumab induces significant changes in lon...

Pharmacology and Toxicology
Avatar
librarian
10 views
Effects of the Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 On Opioid Efficacy in Rat Neuropathic Pain States

Effects of the Mu Opioid Receptor Positive All...

Pharmacology and Toxicology
Avatar
John Traynor
9 views
Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1

Development of NanoBRET cellular target engage...

Pharmacology and Toxicology
Avatar
librarian
9 views
Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters KCa2.2 vs KCa3.1 Ligand Selectivity

Mutation-Induced Pocket Deactivation: How Ser3...

Pharmacology and Toxicology
Avatar
Oliver Koch
9 views
Serine Stabilizes SLC7A11 and Enhances Cystine Influx to Protect Against Acute Pancreatitis

Serine Stabilizes SLC7A11 and Enhances Cystine...

Pharmacology and Toxicology
Avatar
Dan Du
12 views
Hex-MASP for Mapping the Whole-tissue Spatial Proteome and the Intra-brain Distribution of Monoclonal Antibodies

Hex-MASP for Mapping the Whole-tissue Spatial ...

Pharmacology and Toxicology
Avatar
Jun Qu
13 views
Protein Age Bias in Target Degradation by PROTACs

Protein Age Bias in Target Degradation by PROTACs

Pharmacology and Toxicology
Avatar
librarian
9 views
Phosphoproteomics in Daphnia magna as a tool to decipher molecular mechanisms in ecotoxicological studies

Phosphoproteomics in Daphnia magna as a tool t...

Pharmacology and Toxicology
Avatar
Thomas Fröhlich
10 views
Intraventricular infusion to circumvent the blood-brain barrier to gemcitabine.

Intraventricular infusion to circumvent the bl...

Pharmacology and Toxicology
Avatar
Bruno CHAUFFERT
13 views
TRPA1 channel activation by synthetic lipid nanoparticles

TRPA1 channel activation by synthetic lipid na...

Pharmacology and Toxicology
Avatar
librarian
13 views
Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates Nanotherapeutics

Extreme Hydrophobicity of Cytotoxic Drugs Enab...

Pharmacology and Toxicology
Avatar
librarian
15 views
Inhibition of oogenic JNK preserves fertility and ovarian hormones during DNA-damaging cancer therapy

Inhibition of oogenic JNK preserves fertility ...

Pharmacology and Toxicology
Avatar
librarian
25 views
Lysophosphatidic Acid (LPA) Salivary Species Detection and Whole-mount LPA Receptor Localization in Mouse Salivary Gland

Lysophosphatidic Acid (LPA) Salivary Species D...

Pharmacology and Toxicology
Avatar
librarian
26 views
Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A mice

Selective targeting of the oligodendroglial GP...

Pharmacology and Toxicology
Avatar
librarian
19 views
Otenabant is a Selective Antagonist of Human PIEZO1

Otenabant is a Selective Antagonist of Human P...

Pharmacology and Toxicology
Avatar
librarian
20 views
Phytochemical profiling, antioxidant capacity, and in vivo safety assessment of Warrigal spinach (Tetragonia tetragonioides) and Kensington Pride mango (Mangifera indica) extracts using Zebrafish larvae

Phytochemical profiling, antioxidant capacity,...

Pharmacology and Toxicology
Avatar
librarian
18 views
Multidimensional Mechanistic Study of Panax Notoginseng Saponins in the Treatment of Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation

Multidimensional Mechanistic Study of Panax No...

Pharmacology and Toxicology
Avatar
Jian Mo
25 views
Isoquercetin treatment of mouse sickled red blood cells shows a discernible deformability and sickling phenotype

Isoquercetin treatment of mouse sickled red bl...

Pharmacology and Toxicology
Avatar
Moua Yang
22 views
Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling

Triptans reprogram Schwann cells to drive medi...

Pharmacology and Toxicology
Avatar
Alberto Magi
23 views
Organophosphorus pesticide and nerve agent surrogate metabolism by human CYP3A4

Organophosphorus pesticide and nerve agent sur...

Pharmacology and Toxicology
Avatar
Craig McElroy
24 views
Unexpected antidepressant-like effects of temozolomide in a mixed sex-cohort of adult rats: role of hippocampal FADD protein

Unexpected antidepressant-like effects of temo...

Pharmacology and Toxicology
Avatar
librarian
26 views
PM2.5 toxin benzopyrene induces life-limiting inflammation and oxidative stress in the airway by up-regulation of TRPC6 and inactivation of β2AR/CFTR signaling

PM2.5 toxin benzopyrene induces life-limiting ...

Pharmacology and Toxicology
Avatar
Harvey Pollard
32 views
Generation of High-Affinity Anti-GIPR Antagonist Antibodies with Sustained and Non-rebound Weight Loss in DIO Mice by AlfaBodY

Generation of High-Affinity Anti-GIPR Antagoni...

Pharmacology and Toxicology
Avatar
librarian
23 views
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis.

Towards Bayesian-based quantitative adverse ou...

Pharmacology and Toxicology
Avatar
Lola Bajard
32 views
Glucose and fructose differently mediate alcohol cocktail drinking in female and male rats: interaction of glucose and alcohol on post-ingestive behavior

Glucose and fructose differently mediate alcoh...

Pharmacology and Toxicology
Avatar
Ken Wakabayashi
46 views
Kinetics of cortisol and cortisone binding to corticosteroid binding globulin and albumin in vivo

Kinetics of cortisol and cortisone binding to ...

Pharmacology and Toxicology
Avatar
librarian
36 views
A Nonsteroidal Reversal Agent Inhibits Allopregnanolone Modulation of α1β3δ GABAA Receptors

A Nonsteroidal Reversal Agent Inhibits Allopre...

Pharmacology and Toxicology
Avatar
Keith Miller
39 views
Slow Dissociation of Nitazenes from the μ-Opioid Receptor Underlies the Challenge of Overdose Reversal

Slow Dissociation of Nitazenes from the μ-Opio...

Pharmacology and Toxicology
Avatar
librarian
37 views
N-3 Polyunsaturated Fatty Acids Ameliorate Post-infarction Cardiac Dysfunction Through Modulation Of Adiponectin-Ceramide Metabolism

N-3 Polyunsaturated Fatty Acids Ameliorate Pos...

Pharmacology and Toxicology
Avatar
Xiaofei Guo
31 views
Load more