Pharmacology and Toxicology

Oxidative stress and vacuolar variants influence paraquat response in Saccharomyces cerevisiae of different genetic variants

Oxidative stress and vacuolar variants influen...

Pharmacology and Toxicology
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Andres Klein
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IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site

IQM-22110 as a selective KV4.3/KChIP3 modulato...

Pharmacology and Toxicology
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librarian
2 views
Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

Non-Equilibrium Snapshots of Ligand Efficacy a...

Pharmacology and Toxicology
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Georgios Skiniotis
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Validation of a high-throughput screening assay for the characterization of cryoprotective agent toxicity

Validation of a high-throughput screening assa...

Pharmacology and Toxicology
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Rebecca Sandlin
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Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment

Discovery and Development of DC-174 as a Novel...

Pharmacology and Toxicology
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librarian
8 views
In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

In-dwelling microfluidic device for precise an...

Pharmacology and Toxicology
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librarian
3 views
TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

TRPV4 activation enhances LPS-induced IL10 pro...

Pharmacology and Toxicology
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librarian
5 views
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Mechanism of SK2 channel gating and its modula...

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librarian
5 views
Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Neurotoxicity of Propylene Glycol Butyl Ether:...

Pharmacology and Toxicology
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Marie-Gabrielle Zurich
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Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

Endothelial c-IAP2 Loss Amplifies P2X7 Recepto...

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Suellen Oliveira
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Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters

Identification of antibody-drug conjugate payl...

Pharmacology and Toxicology
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Matthew Hall
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Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.

Identification of new KCNT1-epilepsy drugs by ...

Pharmacology and Toxicology
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Jonathan Lippiat
10 views
Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

Intranasal Dantrolene Nanoparticles for Treatm...

Pharmacology and Toxicology
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librarian
5 views
Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

Bisdemethoxycurcumin mitigates Alzheimer disea...

Pharmacology and Toxicology
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Ajay Kumar
10 views
Evaluating the efficacy of LUMPY-NIL herbal powder, dermal Spray and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines

Evaluating the efficacy of LUMPY-NIL herbal po...

Pharmacology and Toxicology
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librarian
9 views
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

RAC1 Regulates Shh-Medulloblastoma Growth via ...

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librarian
5 views
Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

Alcohol Disrupts Neural Differentiation Throug...

Pharmacology and Toxicology
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librarian
12 views
Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

Mitragynine and 7-Hydroxymitragynine: Bidirect...

Pharmacology and Toxicology
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Samuel Obeng
10 views
Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response

Differential responses of murine embryonic ste...

Pharmacology and Toxicology
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librarian
10 views
The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels

The sodium/glucose cotransporter 2 inhibitor e...

Pharmacology and Toxicology
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Karlheinz Hilber
15 views
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids

CHI3L1-Targeted Small Molecules as Glioblastom...

Pharmacology and Toxicology
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librarian
15 views
Promising protocol for in vivo experiments with betulin

Promising protocol for in vivo experiments wit...

Pharmacology and Toxicology
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librarian
15 views
Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer

Discovery and structure-activity relationship ...

Pharmacology and Toxicology
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Fabrice Boyom
16 views
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition

Theanine boosts frontal theta and hippocampal ...

Pharmacology and Toxicology
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Nobuyoshi Matsumoto
13 views
High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells

High-resolution imaging reveals a cascade of i...

Pharmacology and Toxicology
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Pranesh Padmanabhan
12 views
Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures

Screening for cryoprotective agent toxicity an...

Pharmacology and Toxicology
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librarian
12 views
A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

A Mechanism Based Pharmacokinetic/Pharmacodyna...

Pharmacology and Toxicology
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librarian
14 views
Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat

Synaptic Toxicity of OGA Inhibitors and the Fa...

Pharmacology and Toxicology
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librarian
15 views
Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms

Role of adipocyte angiotensinogen or angiotens...

Pharmacology and Toxicology
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librarian
14 views
Advanced Cardiac Organoid Model for Studying Doxorubicin-Induced Cardiotoxicity

Advanced Cardiac Organoid Model for Studying D...

Pharmacology and Toxicology
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Xian Wu
13 views
High-Throughput Evaluation of Cryoprotective Agents for Mixture Effects That Reduce Toxicity

High-Throughput Evaluation of Cryoprotective A...

Pharmacology and Toxicology
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librarian
14 views
Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added In Silico Predictions

Evaluation of the Basis and Performance of Sim...

Pharmacology and Toxicology
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librarian
17 views
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