Pharmacology and Toxicology

BODIPY-Tagged β-Lactams as Selective Quenched Activity-Based Probes to Target Human Neutrophil Elastase

BODIPY-Tagged β-Lactams as Selective Quenched ...

Pharmacology and Toxicology
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librarian
4 views
Molecular Determinants Governing the Antitubercular Activity of Griselimycin

Molecular Determinants Governing the Antituber...

Pharmacology and Toxicology
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Andrew Spira
3 views
Efficacy of SGLT2 Inhibitors in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Preclinical Studies

Efficacy of SGLT2 Inhibitors in Pulmonary Arte...

Pharmacology and Toxicology
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librarian
5 views
Anti-inflammatory and pro-proliferative effects of fasudil in human trisomy 21 neural progenitor cells

Anti-inflammatory and pro-proliferative effect...

Pharmacology and Toxicology
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Diana Bianchi
6 views
Nanoparticle-in-Microparticle Oral Delivery System Based on Drug-Loaded Polymeric Micelles

Nanoparticle-in-Microparticle Oral Delivery Sy...

Pharmacology and Toxicology
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librarian
7 views
Patchouli alcohol suppresses gastric cancer growth and immune evasion via inhibition of the NF-κB/PD-L1 axis

Patchouli alcohol suppresses gastric cancer gr...

Pharmacology and Toxicology
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Kun Hou
6 views
Voltage-Gated Sodium Channel Modulation Differentially Alters ON and OFF Bipolar Cell Contributions to the Rat ERG

Voltage-Gated Sodium Channel Modulation Differ...

Pharmacology and Toxicology
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librarian
5 views
Integrated Skin Sensitization Assessment Using Consensus Modelling and Tiered New Approach Methodology: A SaferSkin Case Study

Integrated Skin Sensitization Assessment Using...

Pharmacology and Toxicology
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librarian
9 views
A Novel Hollow Fiber Infection Model (HFIM) for Antiviral PK/PD studies of CMV infection.

A Novel Hollow Fiber Infection Model (HFIM) fo...

Pharmacology and Toxicology
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librarian
12 views
Cancer-derived Extracellular Vesicles for Targeted Delivery of EGFRvIII siRNA to Glioblastoma, Comparison of siRNA Loading Methods and Efficiency

Cancer-derived Extracellular Vesicles for Targ...

Pharmacology and Toxicology
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librarian
443 views
Red yeast rice-derived MKA ameliorates cardiac hypertrophy in hypertensive rats by inhibiting ERK1/2/c-Fos pathway

Red yeast rice-derived MKA ameliorates cardiac...

Pharmacology and Toxicology
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Xiaoqiu Tan
14 views
Introduction to Single-cell Physiologically-Based Pharmacokinetic (scPBPK) Models

Introduction to Single-cell Physiologically-Ba...

Pharmacology and Toxicology
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librarian
20 views
Discovery of the first small-molecule extracellular inhibitor of KCa3.1

Discovery of the first small-molecule extracel...

Pharmacology and Toxicology
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librarian
15 views
Paralysis Efficiency (ED50) Scales Linearly with Lethality (LD50) in Spider Venoms

Paralysis Efficiency (ED50) Scales Linearly wi...

Pharmacology and Toxicology
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librarian
19 views
Discovery of Novel Ligands for Cryptococcus neoformans

Discovery of Novel Ligands for Cryptococcus ne...

Pharmacology and Toxicology
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Fernando Cagide
25 views
RGS6 regulates Kappa Opioid Receptor-mediated antinociceptivebehaviors

RGS6 regulates Kappa Opioid Receptor-mediated ...

Pharmacology and Toxicology
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Laurie Sutton
20 views
A spoonful of what helps the medicine go down? Improving the reliability of voluntary ingestion for oral dosing in rats and mice

A spoonful of what helps the medicine go down?...

Pharmacology and Toxicology
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librarian
18 views
Partial Differential Equation (PDE) Based Spatial Pharmacometrics in NONMEM: Method of Lines (MOL) Implementation With AI-Assisted Model Development

Partial Differential Equation (PDE) Based Spat...

Pharmacology and Toxicology
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librarian
18 views
Beyond Student's t: A Systematic Exploration of Heavy-Tailed Residual Densities for Outlier Handling in Population PK Modeling

Beyond Student's t: A Systematic Exploration o...

Pharmacology and Toxicology
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librarian
19 views
Delay Differential Equation (DDE) Modeling of CAR-T Cellular Kinetics: Application to BCMA-Targeted (Ide-cel, Orva-cel) and CD19-Targeted (Liso-cel) Therapies

Delay Differential Equation (DDE) Modeling of ...

Pharmacology and Toxicology
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Yan Li
23 views
Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

Matrix metalloproteinases proteolyze RAB prote...

Pharmacology and Toxicology
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librarian
22 views
Acute Toxicological Profile of Pharmaceutical-Grade Nicotinamide Riboside: A Route-Dependent Assessment Across Intravenous, Intramuscular, and Subcutaneous Administration

Acute Toxicological Profile of Pharmaceutical-...

Pharmacology and Toxicology
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Jun Kwon
23 views
Tetracycline-Regulated Inducible CB2 Expression in AtT20 Cells: A Functional Assay for Quantifying Ligand Efficacy

Tetracycline-Regulated Inducible CB2 Expressio...

Pharmacology and Toxicology
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Mark Connor
27 views
vToxiNet: a biologically constrained deep learning framework for interpretable prediction of drug-induced hepatotoxicity

vToxiNet: a biologically constrained deep lear...

Pharmacology and Toxicology
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Hao Zhu
22 views
Short-Term Performance Assay Identifies Functional Benefits and Early Toxicity of Longevity Interventions in Mice

Short-Term Performance Assay Identifies Functi...

Pharmacology and Toxicology
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Alberto Parras
55 views
Suppressing Bone Resorption and Promoting Mineralization with Tetracycline Derivatives

Suppressing Bone Resorption and Promoting Mine...

Pharmacology and Toxicology
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librarian
27 views
A Degron Decoy System Co-opts Pathological Seeding to Enable Clearance of Multimeric α-Synuclein.

A Degron Decoy System Co-opts Pathological See...

Pharmacology and Toxicology
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librarian
23 views
Single-cell transcriptomics reveals a differential response of human bronchial epithelial cell-types to cadmium chloride

Single-cell transcriptomics reveals a differen...

Pharmacology and Toxicology
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librarian
40 views
Oxytocin treats respiratory depression and reduces mortality from fentanyl and the combination of xylazine-fentanyl

Oxytocin treats respiratory depression and red...

Pharmacology and Toxicology
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David Mendelowitz
23 views
Gene III Ergothioneine Ameliorates Exercise-Induced Fatigue by Attenuating Oxidative Stress, Inflammation, and Modulating the AMPK/PGC-1α Signaling Pathway

Gene III Ergothioneine Ameliorates Exercise-In...

Pharmacology and Toxicology
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librarian
24 views
Transcriptomic data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and uranyl nitrate.

Transcriptomic data of larval zebrafish expose...

Pharmacology and Toxicology
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librarian
21 views
Gene III Ergothioneine ameliorates alcoholic fatty liver disease: A dual strategy of accelerated ethanol elimination and reducing oxidative stress

Gene III Ergothioneine ameliorates alcoholic f...

Pharmacology and Toxicology
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Guohua Xiao
24 views
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